Histamine accumulation in the body due to excessive food and alcohol consumption causes gastrointestinal disorders, headaches and migraine. The International Society of DAO Deficiency recommends moderating the intake of food, especially those rich in histamine such as cured meat, smoked products, seafood and typical Christmas dessert, and supplement menu with DAO enzyme in order to promote histamine metabolism. December 2014 –    Christmas time implies, for many people, an alteration of the consumption habits, especially dietary habits. Copious meals and increased alcohol... READ MORE

Interview to Adriana Duelo, nutritionist and expert in DAO deficiency Interview to Adriana Duelo, Nutritionist and expert in DAO Deficiency, by Gemma Busquets of El Punt Avui newspaper   Is it a “myth” that chocolate causes migraine? We are always being told about a list of food because patients described it, but the cause was unknown. Nutritionists do not like to talk about forbidden or recommended food because each one is different. Migraine is one of the effects caused by the accumulation of histamine in plasma. What is histamine? Histamine is a molecule present in all food and... READ MORE

Diamine Oxidase Activity As a Serum Biomarker for Intestinal Mucosal Damage, Appearance of Diarrhea and Malnutrition Due to Anticancer Drugs Jinsei Miyoshi, Hiroshi Miyamoto, Sayo Matsumoto, Yasuteru Fujino, Kumiko Tanaka, Fumika Nakamura, Miwako Kagawa, Takahiro Goji, Shinji Kitamura, Naoki Muguruma, Toshiya Okahisa, Tetsuji Takayama       © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved. Aim: Intestinal mucosal damage due to anticancer drugs which induces QOL impairment and malnutrition is one of major problems for cancer treatment. However, there is... READ MORE

Migraine and different digestive disorders, according to several clinical studies, are symptoms caused by this enzymatic deficiency in the bowel, which affects 20% of the population Europapress 27th March, 2014 – Experts in neurology and gastroenterology have presented the results of three clinical studies, in Infarma Madrid 2014, which suggest that Diamine Oxidase deficiency should be considered a syndrome presenting digestive manifestations (such as constipation, abdominal pain or diarrhoea) and neurological manifestations (as migraine), all of them difficult to treat up to now.... READ MORE

  There are increasing number of new studies in the world linking histamine with migraine, which support and reinforce our research and development projects regarding DAO Deficiency and migraine; as this enzymatic deficiency is one of the main factors causing histamine accumulation in plasma.  Cefhalalgia, 27th November 2013. -  Migrainous people suffering from seasonal allergy and rhinitis experience more severe headaches than people with migraine only, according to the American Migraine Prevalence and Prevention (AMPP) study, carried out by the Universities of Cincinnati (Ohio) and... READ MORE

    Histamine [2-(4-imidazolil)-etilamina] is an important mediator of many biological processes including inflammation, gastric acid secretion, neuromodulation and regulation of the immune function. Due to its powerful pharmacological activity, even in low concentrations, it is necessary to carefully regulate histamine’s synthesis, transport, storage, release and degradation to avoid adverse reactions. Histamine is produced by the human body itself and storaged, in an inactive form, within the metachromatic granules of mast cells and basophil leukocytes, where it remains... READ MORE

Source: Journal of Neuroinmmunology -November 2013.   A few days ago, the ‘Journal of Neuroinmunology’ published an interesting article titled “A focus on mast cells and pain” written by Dr Anne Héron, of the University of Paris, highlighting histamine role in pain regulation and modulation. Mast cells (MC) are immune cells with secretory functions that act locally in peripheral tissues to modulate local hemodynamic, nocieptor activation and pain.  They can also infiltrate in the central nervous system (CNS), especially in the spinal cord and thalamus, but their brain function remains an... READ MORE